Description
DESCRIPTION
Prazicid is a tablet medication for deworming dogs and cats against cestode and nematode infestations. Medicinal form: tablets for oral administration. The appearance of the medication is light yellow tablets with a score line.
COMPOSITION
Each tablet weighing 500mg contains the following active ingredients: praziquantel – 45mg and pyrantel pamoate – 150mg, and the following excipients: lactose and carboxymethylcellulose.
PHARMACOLOGICAL PROPERTIES
Prazicid tablets belong to the group of combined anthelmintic drugs.
The active ingredients, praziquantel, and pyrantel pamoate, provide a broad spectrum of anthelmintic action against all developmental stages of roundworms and tapeworms parasitizing dogs and cats, including Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis, Ancylostoma caninum, Echinococcus granulosus, Alveococcus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobothrium latum, and Multiceps multiceps.
The mechanism of action of praziquantel involves blocking nerve-muscle conductivity in the worms. The mechanism of action of pyrantel pamoate involves blocking neuromuscular transmission, disrupting cell membrane permeability, and inhibiting cholinesterase, leading to paralysis and death of the worms.
When administered orally, praziquantel is well absorbed in the gastrointestinal tract, reaching peak plasma concentration within 1-4 hours, distributed in the organs and tissues of the animal, and primarily excreted in the urine (up to 80%) within 24 hours. Pyrantel pamoate is poorly absorbed, providing prolonged action against worms in the intestines, and is primarily excreted unchanged in the feces (93%).
Prazicid tablets are classified as slightly hazardous substances (Class 4 hazard according to GOST 12.1.007-76) and, at recommended doses, do not exhibit embryotoxic, teratogenic, or sensitizing effects. They are well tolerated by dogs and cats of different breeds and ages.
Prazicid tablets should not be used simultaneously with piperazine and cholinesterase inhibitors.
INDICATIONS
Prazicid tablets are prescribed to dogs and cats for prophylactic and therapeutic purposes against nematode infestations (toxocarosis, toxascariasis, uncinariasis, trichurosis, ancylostomiasis), cestode infestations (teniasis, dipylidiosis, echinococcosis, diphyllobothriosis, mesocestoidosis), and mixed nematode-cestode invasions.
ADMINISTRATION
Prazicid tablets are administered to animals individually, once, during the morning feeding with a small amount of food (e.g., sausage, meat, minced meat, porridge) at the following dose: for dogs — 1 tablet weighing 0.5g per 10kg of animal weight.
There is no need for prior fasting or the use of laxatives. In case of severe infestation, deworming is recommended to be repeated after 10 days.
For preventive purposes, deworming is carried out at a therapeutic dose once every quarter, as well as before each vaccination.
It is important to adhere to the dosing schedule of the medication, as deviations may reduce its effectiveness. If a deworming dose is missed, it should be administered as soon as possible at the same dose.
SPECIAL INSTRUCTIONS
Prazicid tablets should not be used in pregnant females during the first half of pregnancy. Pregnant females should be given the medication with caution, under the supervision of a veterinarian, 3 weeks before the expected delivery date, and nursing females should be given the medication 2-3 weeks after delivery. Prazicid tablets should not be used in puppies and kittens younger than 3 weeks old.
Prazicid tablets are not intended for use in productive animals.
CONTRAINDICATIONS
Contraindications to the use of the medication include individual intolerance to its components (including in the medical history). Prazicid tablets should not be used in animals that are exhausted, suffering from infectious diseases, or recovering.
OVERDOSAGE
In case of overdosage, the animal may experience a depressed state, refusal to eat, excessive salivation, and gastrointestinal upset.
SIDE EFFECTS
No specific effects of the medication have been observed upon initial use and discontinuation.
When administered according to this instruction, animals typically do not experience side effects or complications. In case of increased individual sensitivity to the components of the medication and the occurrence of allergic reactions, the use of the medication should be discontinued, and antihistamines and symptomatic therapy should be administered to the animal.
PRECAUTIONS
When working with the medication, general rules of personal hygiene and safety techniques for handling medicinal products should be observed. Smoking, drinking, and eating are not permitted during work. After completion of work, hands should be washed with warm water and soap. Empty containers from the medication should not be used for domestic purposes; they should be disposed of with household waste.
People with hypersensitivity to the components of the medication should avoid direct contact with Prazicid tablets.
FIRST AID
In case of accidental contact of the medication with the skin or mucous membranes of the eyes, they should be rinsed with plenty of running water. If allergic reactions occur or if the medication accidentally enters the human body, medical attention should be sought immediately (having the medication instruction or label with you).
EXPIRY DATE AND STORAGE
The medication should be stored in its original closed packaging, protected from direct sunlight, separately from food and feed, at a temperature ranging from -10°C to 20°C. The shelf life of the medication under storage conditions is 3 years from the date of manufacture.
PACKAGING
The medication is supplied in strips of 6 tablets made of laminated paper.
